On Monday, Shares of Lexicon Pharmaceuticals, Inc. (NASDAQ:LXRX), surged 61.14% to $13.60, hitting its highest level.
Lexicon Pharmaceuticals declared that the pivotal TELESTAR Phase 3 clinical trial met its primary endpoint, showing the benefit of oral telotristat etiprate in treating cancer patients with carcinoid syndrome that is not adequately controlled by the current standard of care. Telotristat etiprate was discovered using Lexicon’s gene science, based on Nobel Prize-winning technology, and is the company’s first discovery to complete a pivotal Phase 3 clinical trial. If approved, telotristat etiprate would be the first oral treatment successfully developed for carcinoid syndrome and the first addition to the standard of care in more than 16 years.
Top-line results from the Phase 3 study show that patients who added telotristat etiprate to the standard of care at both the 250 mg and 500 mg doses practiced a statistically noteworthy reduction from baseline contrast to placebo in the average number of daily bowel movements over the 12-week study period.
Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery and development of pharmaceutical products for the treatment of human diseases. Its drug development programs comprise telotristat etiprate, an orally-delivered small molecule drug candidate, which is in Phase III clinical trials for the treatment of carcinoid syndrome.
Shares of United States Steel Corp. (NYSE:X), inclined 1.64% to $19.79, during its last trading session.
United States Steel stated a second quarter 2015 net loss of $261 million, or $1.79 per diluted share, which comprised of a $136 million, or $0.93 per diluted share, non-cash write-down of our retained interest in U. S. Steel Canada (USSC) and a net loss of $10 million, or $0.07 per diluted share, related to non-cash restructuring and other charges. This contrast to a second quarter 2014 net loss of $18 million, or $0.12 per diluted share, and a first quarter 2015 net loss of $75 million, or $0.52 per diluted share.
Segment loss before interest and income taxes was $104 million, or $27 per ton, for the second quarter of 2015 contrast to segment loss before interest and income taxes of $21 million, or $5 per ton, in the first quarter of 2015 and segment earnings before interest and income taxes of $132 million, or $26 per ton, in the second quarter of 2014.
United States Steel Corporation produces and sells flat-rolled and tubular steel products in North America and Europe. It operates through three segments: Flat-Rolled Products (Flat-Rolled), U. S. Steel Europe (USSE), and Tubular Products (Tubular). The Flat-Rolled segment offers slabs, rounds, strip mill plates, sheets, and tin mill products. This segment serves customers in the service center, conversion, transportation, construction, container, and appliance and electrical markets.
Finally, Calpine Corp. (NYSE:CPN), ended its last trade with -4.04% loss, and closed at $17.56.
The Environmental Protection Agency’s (EPA’s) release of the Clean Power Plan represents a seminal moment for the power generation industry. Based on statements by President Obama and the EPA, it appears the plan mandates noteworthy but achievable CO2 emissions reductions while giving the states broad discretion in how to achieve those aims. Specifically, the plan provides a framework that will allow states to adopt a market-based approach to achieving reductions, easing the states’ burden while allowing market economics to decide the best mix of generation resources to achieve the aim. Importantly, these emissions reductions will be realized in a manner that ensures continued affordable and reliable electricity. Calpine Corporation (CPN) believes the plan, as broadly described, is a workable and achievable approach to control CO2 emissions that will benefit generations to come.
“The Clean Power Plan represents a commitment to ongoing the transition from carbon-intensive generation to efficient, low-carbon generation,” said Thad Hill, President and Chief Executive Officer of Calpine. “This flexible, market-based solution will reward the companies that invest and have invested smartly in cleaner generation. We applaud the EPA for its efforts throughout this collaborative process and look forward to working with the agency, states and other stakeholders as the rule is ultimately implemented.”
Calpine believes that a strong commitment to environmentally responsible electrical generation is a key element to achieving our vision of being the premier power generation company in the United States. As the nation’s largest generator utilizing natural gas, our portfolio of assets is well positioned to assist achieve these emissions reductions and sustain reliable integration of renewables.
Calpine Corporation, a wholesale power generation company, owns and operates natural gas-fired and geothermal power plants in North America. It operates natural gas-fired combustion turbines and renewable geothermal conventional steam turbines.
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