On Thursday, Shares of Biocept Inc (NASDAQ:BIOC), gain 2.05% to $1.99, after Biocept, Inc. is a cancer diagnostics company. The Company develops and commercializes circulating tumor cell (CTC) and circulating tumor DNA (ctDNA), tests utilizing a standard blood sample.
Biocept, Inc. (BIOC) declared the presentation of study data at the International Association for the Study of Lung Cancer’s (IASLC) 16th Annual World Conference on Lung Cancer in Denver. “Detection of Aberrant ALK Expression from Circulating Tumor Cells for Accurate Monitoring of ALK Driven Non-Small Cell Lung Cancer” will be presented on September 7, 2015, and will describe the detection of RNA-based targets using Biocept’s proprietary liquid biopsy platform.
Earlier this year, Biocept and Insight Genetics declared a joint venture to combine platform technologies to study RNA-based biomarker detection in circulating tumor cells (CTCs). Data demonstrate that Biocept’s proprietary CTC capture technology is compatible for detecting RNA-based targets such as ALK, which is a known driver of non-small cell lung cancer (NSCLC). Using Insight Genetics’ proprietary ALK detection assay, the two companies have been able to demonstrate the feasibility of performing RNA-based detection of ALK in both cell lines and patient samples. These studies demonstrate that Biocept’s proprietary CTC capture technology, coupled with Insight Genetics’ RNA-based biomarker detection assays, could provide a viable strategy to accurately monitor biomarker status in NSCLC patient populations. Biocept has formerly demonstrated the ability to detect and quantify ALK translocations at the DNA level.
“These data further support Biocept’s ability to scale our liquid biopsy platform across a number of different biomarkers,” said Biocept’s Senior Vice President and Chief Scientific Officer Lyle Arnold, PhD. “Biocept has already demonstrated the ability to validate biomarkers based on protein expression, in addition to DNA copy number and mutations. The addition of RNA expression to the list improvements our potential for discovery and clinical utility.”
“Through our joint venture of combining Biocept’s CTC capture platform and Insight Genetics’ ALK qPCR assay, we have been able to successfully detect ALK fusions from blood, something only dreamed about just a few years ago,” said Stephan W. Morris, MD, Insight Genetics’ Scientific Founder and Chief Scientific Officer. “Our partnership will now build upon these initial data with the aim of making clinical testing from liquid biopsies a standard of care.”
Biocept, Inc., a cancer diagnostics company, develops and commercializes proprietary circulating tumor cell (CTC) and circulating tumor DNA tests utilizing a standard blood sample. The company’s tests provide information to oncologists that enable them to select the appropriate treatment for their patients based on detailed data on the characteristics of tumors.
Shares of Gilead Sciences, Inc (NASDAQ:GILD), declined -2.26% to $101.91, during its last trading session.
Gilead Sciences, Inc. (GILD) declared that a Phase 3 study evaluating its investigational fixed-dose combination of emtricitabine and tenofovir alafenamide (200/10 mg and 200/25 mg) (F/TAF) for the treatment of HIV-1 infection met its primary objective. The ongoing study was designed to explore the efficacy and safety of F/TAF-based regimens among virologically suppressed adult patients switching from HIV treatment regimens containing emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) (Truvada®). At Week 48, the F/TAF-based regimens and the TDF-based regimens achieved similar rates of virologic suppression based on the proportion of patients with HIV RNA levels (viral load) of less than 50 copies/mL (94.3 percent for F/TAF-based regimens as compared to 93.0 percent for TDF-based regimens; difference in percentages: 1.3 percent, 95 percent CI: -2.5 percent to 5.1 percent).
Contrast to the TDF-based regimens, the F/TAF-based regimens demonstrated statistically noteworthy differences in mean bone mineral density (BMD) at the hip and spine (p<0.001) and in the median change in estimated glomerular filtration rate (eGFR) (p<0.001). General safety and discontinuation rates due to adverse events were comparable between the two arms. The most commonly stated adverse events comprised upper respiratory tract infection, diarrhea, nasopharyngitis, headache and bronchitis. Both regimens were generally well tolerated. Gilead plans to submit these data for presentation at a scientific conference in 2016.
“For more than a decade, Truvada has been a cornerstone of HIV therapy, and the results of this and other recent trials demonstrate the potential of F/TAF to become a next-generation backbone,” said Norbert Bischofberger, PhD, Executive Vice President, Research and Development and Chief Scientific Officer, Gilead Sciences. “The results from this study reinforce the efficacy, in addition to the renal and bone safety advantages of TAF for patients who face a lifetime of treatment.”
In April 2015, Gilead filed a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) for two fixed-dose combinations of F/TAF (200/10 mg and 200/25 mg), and the FDA has set a target review date under the Prescription Drug User Fee Act of April 7, 2016. A Marketing Authorization Application (MAA) in the European Union for F/TAF was fully validated on May 28, 2015.
Gilead Sciences, Inc., a biopharmaceutical company, discovers, develops, and commercializes medicines in areas of unmet medical need in North America, South America, Europe, and the Asia-Pacific. The company’s products comprise Stribild, Complera/Eviplera, Atripla, Truvada, Viread, Emtriva, Tybost, and Vitekta for the treatment of human immunodeficiency virus (HIV) infection in adults; and Harvoni, Sovaldi, Viread, and Hepsera products for the treatment of liver disease.
Finally, ZIOPHARM Oncology Inc (NASDAQ:ZIOP), ended its last trade with -3.96% loss, and closed at $8.72, after ZIOP, is a biopharmaceutical company. The Company is engaged in the acquisition, development and commercialization of a portfolio of cancer therapies through synthetic biology.
ZIOPHARM Oncology, Inc. (ZIOP), declared that Laurence J.N. Cooper, M.D., Ph.D., Chief Executive Officer, will present at the Wells Fargo 10th Annual Health Care Conference on Thursday, September 10th, 2015 at 1:20 p.m. ET. The conference is being held at The Hyatt Regency Hotel in Boston.
ZIOPHARM Oncology, Inc., a biotechnology company, employs gene expression, control, and cell technologies to deliver cell-based therapies for the treatment of cancer. Its synthetic immuno-oncology programs, in joint venture with Intrexon Corporation and the MD Anderson Cancer Center, comprise chimeric antigen receptor T cell (CAR-T) and other adoptive cell based approaches that use both non-viral and viral gene transfer methods for broad scalability.
DISCLAIMER:
This article is published by www.wsnewspublishers.com. The Content included in this article is just for informational purposes only. All information used in this article is believed to be from reliable sources, but we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, or reliability with respect to this article.
All visitors are advised to conduct their own independent research into individual stocks before making a purchase decision.
Information contained in this article contains forward-looking information within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, counting statements regarding the predictable continual growth of the market for the corporation’s products, the corporation’s ability to fund its capital requirement in the near term and in the long term; pricing pressures; etc.
Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, aims, assumptions, or future events or performance may be forward looking statements. Forward-looking statements are based on expectations, estimates, and projections at the time the statements are made that involve a number of risks and uncertainties, which could cause actual results or events to differ materially from those presently anticipated. Forward looking statements may be identified with such words as expects, will, anticipates, estimates, believes, or by statements indicating certain actions may, could, should/might occur.
