On Tuesday, Shares of bluebird bio Inc (NASDAQ:BLUE), lost -1.47% to $80.63.
bluebird bio, declared that Marina Cavazzana, M.D., Ph.D., professor of hematology and director of the Department of Biotherapy at Hospital Necker, University Paris Descartes and lead investigator for the HGB-205 clinical study, presented a review of the clinical study experience with lentiviral-based gene therapies for beta-thalassemia at the 10th Annual Cooley’s Anemia Foundation Symposium in Chicago recently.
Professor Cavazzana summarized results from HGB-205, an ongoing clinical study using LentiGlobin® BB305 for the treatment of beta-thalassemia major and severe sickle cell disease, which were presented earlier this year at the Annual Congress of the European Hematology Association. She also offered an update on subject 1003, a patient with beta-thalassemia major treated by Professor Cavazzana in 2007 in the LG001 study using the first-generation HPV569 lentiviral vector. Following about seven years of transfusion independence, subject 1003 has recently required two blood transfusions after experiencing clinical symptoms of anemia. Importantly, both the expression of HbAT87Q and the vector copy number in peripheral blood leukocytes, a measure of the persistence of the gene therapy, have remained largely unchanged. The safety profile for both vectors is compriseent with autologous transplantation, with no gene-therapy related serious adverse events.
bluebird bio, Inc., a clinical-stage biotechnology company, focuses on developing transformative gene therapies for severe genetic and rare diseases. Its advanced product candidate is Lenti-D, which is in phase II/III clinical studies for the treatment of childhood cerebral adrenoleukodystrophy, a rare, hereditary neurological disorder affecting young boys; and LentiGlobin that is in phase I/II clinical studies for the treatment of beta-thalassemia major and severe sickle cell disease (SCD) in France, in addition to a phase I study in the United States for the treatment of severe SCD.
Shares of Crown Holdings, Inc. (NYSE:CCK), inclined 3.21% to $52.79, during its last trading session.
Crown Holdings, declared its financial results for the third quarter ended September 30, 2015.
Third Quarter Highlights
- Earnings per share $1.01; Before Certain Items $1.34, counting $0.21 of unfavorable currency translation
- YTD earnings per share $2.35; Before Certain Items $2.89, counting $0.41 of unfavorable currency translation
- Earnings per share before certain items on a constant-currency basis grew 14% in third quarter, 12% YTD
- On a constant-currency basis, Q3 revenue grew 6%, segment income grew 13%
- Global beverage can volumes grew 13% in the quarter over 2014
Net sales in the third quarter were $2,460 million, counting $281 million of unfavorable currency translation, contrast to $2,594 million in the third quarter of 2014.
Segment income (a non-GAAP measure defined by the Company as gross profit not taking into account the impact of fair value adjustments to inventory attained in an acquisition and the timing impact of hedge ineffectiveness, less selling and administrative expense) was $328 million in the third quarters of both 2015 and 2014, and comprised $41 million of unfavorable currency translation in 2015 contrast to 2014.
Crown Holdings, Inc. designs, manufactures, and sells packaging products for consumer goods in Americas, Europe, and the Asia Pacific. The company’s products comprise aluminum beverage cans and ends, and other packaging products to beverage and beer companies; food cans and ends, counting two-and three-piece cans in various shapes and sizes for food marketers; and aerosol cans and ends for manufacturers of personal care, food, household, and industrial products.
Finally, Shares of Great Lakes Dredge & Dock Corporation (NASDAQ:GLDD), ended its last trade with 2.37% gain, and closed at $4.32.
Great Lakes Dredge & Dock Corporation, the largest provider of dredging services in the United States and a major provider of environmental and remediation services, would like to update its investors on several important declarements.
Great Lakes Dredge & Dock Corporation provides dredging services in the United States and internationally. It operates in two segments, Dredging and Environmental & Remediation. The Dredging segment is involved in capital dredging that comprises of port expansion projects, land reclamations, trench digging for pipelines, tunnels and cables, and other dredging related to the construction of breakwaters, jetties, canals, and other marine structures.
