On Monday, Exelixis, Inc. (NASDAQ:EXEL)’s shares inclined 2.99% to $3.79.
Exelixis, Inc. (EXEL) declared positive results from a two-stage phase 2 investigator-sponsored trial (IST) evaluating cabozantinib in patients with advanced RET-rearranged lung cancers. Data were stated for the first stage, which enrolled 16 patients. The objective response rate (ORR) was 38% (6/16), with a median duration of response of 8 months. Although the trial is still accruing, it has already met its primary endpoint, surpassing the predefined targeted number of five objective responses. Alexander Drilon, M.D. of New York’s Memorial Sloan Kettering Cancer Center (MSKCC) will present the data (Abstract #8007) recently during an oral abstract session at the 2015 Annual Meeting of the American Society of Clinical Oncology in Chicago, Illinois.
Study Results
At the time of data cut-off, 20 patients had been treated and 18 were evaluable. Data were presented for the 16 patients enrolled in the first stage of the trial. The median age for patients in the first stage of the trial was 59 (range 38-80 years), and 62 percent (10/16) of these were female. All patients in the first stage had adenocarcinoma, the median number of prior lines of chemotherapy was 1, and 31% of patients had received ≥ 2 lines of prior chemotherapy.
PFS and OS are secondary endpoints. The median PFS was 7 months (95% CI 5-NA). The median OS was 10 months (95% CI 8-NA) with a median follow-up of 24 months.
Exelixis, Inc., a biopharmaceutical company, develops and sells small molecule therapies for the treatment of cancer in the United States. The company offers COMETRIQ, an inhibitor of multiple receptor tyrosine kinases for the treatment of patients with progressive, metastatic medullary thyroid cancer. It is also evaluating cabozantinib in various development programs comprising about 45 clinical trials, counting 2 ongoing phase 3 pivotal trials focusing on metastatic renal cell carcinoma (mRCC) and advanced hepatocellular carcinoma (HCC).
VF Corp (NYSE:VFC)’s shares gained 2.33% to $72.92.
VF Corporation (VFC), a global leader in branded apparel, footwear and accessories, declared that Steven E. Rendle, 55, has been designated President & Chief Operating Officer at the company and has been elected to VF’s Board of Directors. He will report to Eric Wiseman, VF’s Chairman and Chief Executive Officer.
In his role as President & Chief Operating Officer, Rendle will oversee all of VF’s business coalitions worldwide: Outdoor & Action Sports, Jeanswear, Imagewear, Sportswear and Contemporary Brands. He will also be responsible for VF’s global Supply Chain and Direct-to-Consumer platforms.
V.F. Corporation designs, manufactures, markets, and distributes branded lifestyle apparel, footwear, and accessories in the United States and Europe. The company offers outdoor apparel, footwear and equipment, youth culture/action sports-inspired footwear, handbags, luggage, backpacks, totes, accessories, merino wool socks, women’s activewear, and travel accessories under the The North Face, Vans, Timberland, Kipling, Napapijri, Jansport, Reef, Smartwool, Eastpak, lucy, and Eagle Creek brands.
At the end of Monday’s trade, Omnicom Group Inc. (NYSE:OMC)‘s shares dipped -0.08% to $72.63.
While the media comments on AutoNation’s 10 millionth car sale and $20 million ad campaign with Zimmerman Advertising in recognition of the benchmark, it’s time to put the microscope to over 15 years of partnership between the nation’s largest auto retailer and Omnicom Group Inc. (OMC)’s retail growth machine. Mutual ambition and commitment to results has meant not only an enduring professional relationship, but the generation of comprising success through a period of transition for the advertising industry and a protracted economic downturn.
Since AutoNation partnered with Zimmerman 15+ years ago, the days of simple TV, radio and print ads have fully evolved into much more. While AutoNation continued to buy up local and regional dealerships around the country, Zimmerman paid close attention to retail trends and expanded to integrate their agency for the changing landscape.
The launch of the largest ad campaign in AutoNation history follows noteworthy milestones for both client and agency. While AutoNation made a bold move towards becoming a national retail chain in 2013 by replacing all localized brand names throughout the country with the company’s corporate moniker, Zimmerman invested and accomplished construction on a new headquarters for their fast-growing team and client roster; moving into the only state-of-the-art advertising hub of its kind in the nation.
Omnicom Group Inc., together with its subsidiaries, operates as an advertising, marketing, and corporate communications services company in the Americas, Europe, the Middle East, Africa, and the Asia pacific. It offers services in advertising, customer relationship management, public relations, and specialty communications areas.
WisdomTree Investments, Inc. (NASDAQ:WETF), ended its Monday’s trading session with 0.91% gain, and closed at $22.10.
WisdomTree Investments, Inc. (WETF) declared the hire of Kurt MacAlpine as Executive Vice President-Head of Global Distribution. In a newly created role, Mr. MacAlpine will oversee WisdomTree`s ETP sales and distribution initiatives globally and join WisdomTree`s executive administration team. He joins WisdomTree from McKinsey & Company where he was a Partner and Leader of the North American Asset Administration practice.
As a Partner at McKinsey & Company, Kurt managed global consulting teams in the asset administration and wealth administration industries on topics related to distribution, marketing, product development, international expansion, strategy and M&A. He has extensive experience working with domestic and foreign firms in North America, Asia and Europe. Kurt was also a member of McKinsey`s Global Asset and Wealth Administration Operating Committee.
WisdomTree Investments, Inc., through its auxiliaries, operates as an exchange-traded funds (ETFs) sponsor and asset manager. It offers ETFs in equities, currency, fixed income, and alternatives asset classes.
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