On Wednesday, Shares of Chesapeake Energy Corporation (NYSE:CHK), lost -3.49% to $13.56, as oil prices maintained losses Wednesday after weekly U.S. inventory data showed that crude stockpiles shrank but production rose to a new record.
Light, sweet crude for July delivery recently fell 91 cents, or 1.5%, to $60.35 a barrel on the New York Mercantile Exchange. Brent, the global benchmark, fell $1.27, or 1.9%, to $64.22 a barrel on ICE Futures Europe.
Chesapeake Energy Corporation engages in the acquisition, exploration, and development of properties for the production of oil, natural gas and natural gas liquids (NGL) from underground reservoirs in the United States. It holds interests in natural gas resource plays, counting the Haynesville/Bossier Shales in northwestern Louisiana and East Texas.
Shares of MannKind Corp. (NASDAQ:MNKD), inclined 6.33% to $5.54, during its last trading session.
MannKind Corporation, declared that it will present at Goldman Sachs 36th Annual Global Healthcare Conference on Wednesday, June 10, 2015 at 8:40 am (PT) at the Terranea Resort in Rancho Palos Verdes, California.
MannKind Corporation, a biopharmaceutical company, focuses on the discovery, development, and commercialization of therapeutic products for diabetes in the United States. Its lead product is AFREZZA inhalation powder, an insulin to control high blood sugar in adult patients with type 1 and type 2 diabetes. MannKind Corporation was founded in 1991 and is headquartered in Valencia, California.
At the end of Wednesday’s trade, Shares of Bristol-Myers Squibb Company (NYSE:BMY), lost -0.15% to $65.70.
Bristol-Myers Squibb Company, declared that 14 abstracts on Orencia have been accepted for presentation at the 2015 annual meeting of the European League Against Rheumatism (EULAR), to be held June 10-13 in Rome, Italy. Several of this year’s abstracts will focus on the safety and efficacy of Orencia in rheumatoid arthritis (RA) patients with anti-citrullinated protein antibodies (ACPA), which is a marker of worse prognosis and more progressive disease.
“Biologic markers, like ACPA, are key to assisting rheumatologists diagnose RA patients earlier in the disease process,” said Douglas Manion, M.D., Head of Specialty Development, Bristol-Myers Squibb. “As a leader in immunoscience, Bristol-Myers Squibb is proud to present new results at EULAR that will provide further data on the activity of Orencia in this patient population.”
Bristol-Myers Squibb Company discovers, develops, licenses, manufactures, markets, distributes, and sells biopharmaceutical products worldwide. It provides chemically-synthesized drugs or small molecules, and biologics in various therapeutic areas, counting virology comprising human immunodeficiency virus infection (HIV); oncology; neuroscience; immunoscience; and cardiovascular.
Finally, Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY), ended its last trade with -1.89% surge, and closed at $128.84.
Alnylam Pharmaceuticals, declared that it has initiated a Phase 1 clinical trial with ALN-AS1, a subcutaneously administered investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 (ALAS1) for the treatment of acute hepatic porphyrias, counting acute intermittent porphyria (AIP). The Phase 1 trial of ALN-AS1 will be conducted initially in AIP patients who are asymptomatic “high excreters” (ASHE). These ASHE subjects have a defined mutation in the porphobilinogen deaminase (PBGD) gene and elevated urinary levels of aminolevulinic acid (ALA) and porphobilinogen (PBG), but do not have a current history of porphyria attacks or disease activity. Subsequently, the trial is designed to enroll AIP patients who experience recurrent porphyria attacks. The company anticipates to present initial clinical data from this trial in early 2016.
ALN-AS1 is a subcutaneously administered, investigational RNAi therapeutic that employs Alnylam’s ESC-GalNAc delivery technology. ESC-GalNAc-siRNA conjugates are designed to achieve targeted delivery of RNAi therapeutic to hepatocytes through uptake by the asialoglycoprotein receptor, and enable subcutaneous dosing with raised potency and durability and a wide therapeutic index. In pre-clinical studies, multi-dose administration of ALN-AS1 led to rapid, dose-dependent, and long-lasting knockdown of the ALAS1 mRNA in the liver of non-human primates, with an ED50 of about 1.25 mg/kg. Further, in a rat model of AIP, ALN-AS1 administration at doses as low as 2.5 mg/kg resulted in a complete blunting of phenobarbital-induced production of ALA and PBG, the toxic heme intermediates in AIP. Pre-clinical studies with RNAi therapeutics targeting ALAS1 have been published by Alnylam and collaborators formerly (Yasuda et al., Proc Natl Acad Sci USA 2014;111(21):7777-7782).
Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, discovers, develops, and commercializes novel therapeutics based on RNA interference. The company’s clinical development programs comprise Patisiran and Revusiran, which are in Phase III clinical trials for the treatment of transthyretin-mediated amyloidosis; ALN-AT3 that is in Phase I clinical trial for hemophilia and rare bleeding disorders.
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