On Friday, Arrowhead Research Corp (NASDAQ:ARWR)’s shares inclined 2.84% to $5.80.
Arrowhead Research Corporation (ARWR), a biopharmaceutical company developing targeted RNAi therapeutics, is hosting an analyst day in New York, with a presentation starting at 11:00 a.m. EDT to talk about top-line findings from the Heparc-2001 Phase 2a clinical study of ARC-520, its candidate for the treatment of chronic hepatitis B infection. Additionally, the company will talk about findings from a study of 9 chimpanzees that have been treated monthly with ARC-520 for between 6 and 11 months with a background therapy of nucleotide/nucleoside analog inhibitors (NUCs) tenofovir and/or entecavir.
Key findings:
Arrowhead’s proprietary DPC™ platform can effectively and compriseently knock down target genes in humans
HBV E-antigen positive (HBeAg-positive) patients on a background of chronic entecavir receiving a 4 mg/kg single-dose of ARC-520 showed a mean maximal 92% (1.2 log) reduction in circulating HBeAg and a best reduction of 98% (1.7 log). Similar mean maximal reductions were also demonstrated in HBV core-related antigen (HBcrAg) from both HBeAg-negative and -positive patients. ARC-520 is designed to silence all gene products expressed by HBV cccDNA, so this data suggests that it may be substantially disrupting additional viral functions.
Arrowhead Research Corporation develops novel drugs to treat intractable diseases in the United States. The company’s principal product candidates comprise ARC-520, an RNAi-based therapeutic that is in Phase IIa clinical trial to treat chronic hepatitis B virus infection; and ARC-AAT, a novel unlocked nucleobase analog containing RNAi-based therapeutic for the treatment of liver disease associated with alpha-1 antitrypsin deficiency.
Textron Inc. (NYSE:TXT)’s shares gained 0.89% to $38.43.
Textron Systems Unmanned Systems, a Textron Inc. (TXT) business, declared that the company offered its equipment and personnel in support of a multi-day wildfire response and decision support effort in Idaho with the U.S. Department of Interior and U.S. Forest Service. Held in the area of Tepee Springs, where tens of thousands of acres were involved in or threatened by wildfire activity at its peak, Textron Systems operators worked alongside federal agencies to provide real-time situational awareness and data to support the speed and accuracy of decision making. Information on burn intensity, fuels and heat concentrations were offered in real time.
The Aerosonde™ Small Unmanned Aircraft System (SUAS) has amassed more than 100,000 flight hours in commercial and military operations around the world. Among these are scientific and meteorological missions, from the eye of hurricane Noel to Antarctica. The Aerosonde aircraft is outfitted with sensors to give responders real-time data on fire growth, burn intensity, fuels and heat concentrations. Aerosonde is also equipped to carry numerous payloads in a single flight; for example, advanced electro-optic/infrared payloads for day-and-night persistent oversight of the influenced area, in addition to communications relay to extend the reach of responders’ equipment. Using Lycoming’s EL-005 engine, the Aerosonde is the only system in its class with a propulsion system completely supported by a manufacturer with unmatched manned aviation expertise, counting a Federal Aviation Administration (FAA) Production Certificate. With that comes Lycoming Engines’ established processes for engine development, production, services and support.
Textron Inc. operates in the aircraft, defense, industrial, and finance businesses worldwide. It operates through five segments: Textron Aviation, Bell, Textron Systems, Industrial, and Finance.
At the end of Friday’s trade, Chicago Bridge & Iron Company N.V. (NYSE:CBI)‘s shares surged 3.22% to $38.78.
CB&I (CBI) recently declared it has been awarded a contract by Total Petrochemicals & Refining USA, Inc. to provide its proprietary ethylene technology and front-end engineering and design (FEED) services for a projected new ethane cracker located in Port Arthur, Texas. The projected cracker will have a capacity of one million metric tons per year of ethylene. CB&I will provide FEED services and the process license for its latest, proven ethylene technology, counting seven highly selective SRT® (short residence time) cracking heaters.
Chicago Bridge & Iron Company N.V. provides conceptual design, technology, engineering, procurement, fabrication, modularization, construction, commissioning, maintenance, program administration, and environmental services worldwide. The company’s Engineering, Construction and Maintenance segment offers engineering, procurement, and construction services for energy infrastructure facilities, in addition to comprehensive and integrated maintenance services.
Unum Group (NYSE:UNM), ended its Friday’s trading session with -1.42% loss, and closed at $31.95.
Unum Group (UNM) will release its third quarter results on Wednesday, Oct. 28, at about 4 p.m. Eastern. The earnings news release and the financial supplement will be accessible in the Investors section of the company’s website, which can be directly accessed at www.investors.unum.com.
Unum Group, together with its auxiliaries, provides group and individual disability insurance products in the United States and the United Kingdom. The company operates through three segments: Unum US, Unum UK, and Colonial Life. It provides group long-term and short-term disability, group life, accidental death and dismemberment, individual disability, supplemental and voluntary products, and group and individual long-term care insurance products, in addition to accident, sickness and disability products, life products, and cancer and critical illness products.
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