On Monday, Shares of Medtronic PLC (NYSE:MDT), gained 2.49% to $75.76.
Medtronic plc, declared the initiation of the REALITY Study (DiRectional AthErectomy + Drug-coAted BaLloon to Treat Long, Calcified FemoropopliTeal ArterY Stenoses) to evaluate patient outcomes following adjunctive use of directional atherectomy and drug-coated balloon (DCB) treatment of patients with symptomatic peripheral arterial disease (PAD) in long, calcified lesions in the superficial femoral artery (SFA) and/or popliteal artery. The study is sponsored and will be managed by VIVA Physicians, and will have multidisciplinary representation in leadership.
The REALITY Study is a multi-center, prospective, single-arm observational angiographic and duplex ultrasound core lab adjudicated study that will enroll 250 subjects at up to 20 sites across the U.S. with primary patency assessed by duplex ultrasound at 12-months. Patients will be followed to 24 months to determine CD-TLR. Medtronic`s directional atherectomy systems and IN.PACT® Admiral® drug-coated balloon will be studied in REALITY. The study also comprises several important core lab adjudicated sub-analyses counting the intravascular ultrasound assessment of the efficiency of directional atherectomy to debulk various plaque morphologies counting severe calcium in long lesions preceding to DCB deployment and the validation of the Peripheral Arterial Calcium Scoring Scale (PACSS) to assess the impact of severe vessel calcification on Major Adverse Clinical Events (MACE) from the procedure through 12 months. Importantly, a health economics and Quality of Life assessment will also be comprised as part of REALITY.
“As standalone treatments for peripheral arterial disease, directional atherectomy and DCBs have demonstrated strong clinical results. However, challenges in treating long and severely calcified femoropopliteal lesions remain counting the associated provisional stent rate with DCB and reintervention rates with directional atherectomy over the long-term,” said Dr. Krishna Rocha-Singh, chief scientific officer, Prairie Heart Institute at St. John`s Hospital; Springfield, Ill. “The REALITY study was driven by the need to look at a viable treatment paradigm that combines the use of directional atherectomy and DCB therapy to address these challenges.”
Medtronic plc manufactures and sells device-based medical therapies worldwide. The company’s Cardiac and Vascular Group segment offers pacemakers, implantable cardioverter defibrillators, implantable cardiac resynchronization therapy devices, AF products, diagnostics and monitoring devices, and remote monitoring and patient-centered software; and heart valves, percutaneous coronary intervention stent products, surgical valve replacement and repair products, endovascular stent grafts, and peripheral vascular intervention products.
Shares of Apache Corporation (NYSE:APA), inclined 1.72% to $47.94, during its last trading session.
Apache Corporation, declared noteworthy discoveries on two exploration wells in the Beryl area of the U.K. North Sea. The company also drilled two noteworthy development wells in the Beryl area, from which no reserves have been formerly booked. Additionally, Apache declared a large discovery at its Seagull prospect, which lies about 50 miles south of the company’s Forties Field, the largest oil field in the U.K. North Sea.
The K and Corona wells are the first exploratory prospects drilled by Apache in the Beryl area. Each discovery proves a separate geologic concept that assists to de-risk additional drilling locations. Apache estimates the K and Corona discoveries, combined with the success at Seagull, represent likely net recoverable reserves of 50 million to more than 70 million barrels of oil equivalent (MMboe). Future appraisal drilling will enable the company to further define the upside potential beyond 70 MMboe. Apache’s proved reserves in the North Sea at yearend 2014 were about 140 MMboe.
“Apache’s exploration program in the high-potential Beryl area is off to an exceptional start. The success of our first two exploration wells at Beryl, combined with the Seagull discovery, could improvement our total North Sea proved reserve base by more than 50 percent. Importantly, results obtained from the wells declared recently emphasize the quality of our seismic surveys and the accuracy of our geologic model in the Beryl area,” Thomas E. Voytovich, Apache’s executive vice president – International and Offshore and E&P Technology, said. “Our large discovery at Seagull will likely have a longer investment time-horizon as it may require dedicated production facilities, but it is predictable to have a very meaningful impact on Apache’s medium- and long-term production in the region. We look forward to discussing the economics and details of these discoveries, together with a review of our extensive North Sea prospect inventory during our North Sea Region webcast Nov. 17.”
Apache Corporation, an independent energy company, explores, develops, and produces natural gas, crude oil, and natural gas liquids. It operates onshore and offshore assets primarily in the Permian Basin, the Anadarko basin in western Oklahoma, and the Texas Panhandle, Gulf Coast areas of the United States, in addition to in Western Canada.
Finally, Shares of American Express Company (NYSE:AXP), ended its last trade with 0.93% gain, and closed at $73.94.
American Express, declared that Cherrytree/ Interscope recording artist Ellie Goulding and actress, Scarlett Johansson have been selected as the next pairing in its popular live stream music series, ‘American Express Unstaged,’ in partnership with Vevo and YouTube. Goulding’s November 11th concert from New York’s Hammerstein Ballroom at 8:00 PM EST will be directed by Johansson and live streamed at AmexUNSTAGED.com and via the Amex Unstaged app. The performance is set to take place just days after the release of Ellie Goulding’s new album “Delirium” with the Unstaged performance being her first full live show featuring tracks off her new album.
“I am so excited for my forthcoming ‘American Express Unstaged’ performance and to know I’ll have Scarlett Johansson directing the live stream is really cool” said Goulding. “I wanted to go into this album making everything bigger and better and from the looks of this partnership we are achieving both of those aims. I can’t wait to perform my new album for the fans that will be at the show in New York City in addition to for all my other fans around the world that will have a chance to catch the live stream online.”
Ellie Goulding’s third album, Delirium is the follow-up to 2012’s Halcyon, which cemented Goulding’s status as a global artist. The British singer and songwriter has sold over six million albums and 20 million singles worldwide and has scored six successive platinum singles “Lights,” “Anything Could Happen,” “I Need Your Love,” “Burn,” “Outside” and “Love Me Like You Do” (which went to No. 1 on the iTunes chart in over 70 countries and broke the record for most streamed song in one week on Spotify). Goulding has racked up over one billion plays on both YouTube and Spotify and has performed at the world’s biggest festivals, counting Coachella, Bonnaroo, Lollapalooza, Glastonbury, and Outside Lands. In addition, she has also collaborated with top producers such as Calvin Harris, Skrillex, Zedd, Diplo, and Max Martin (on “Love Me Like You Do” and her most recent single “On My Mind”). The lead single from Delirium, “On My Mind” was released to rave reviews.
American Express Company, together with its auxiliaries, provides charge and credit payment card products and travel-related services to consumers and businesses worldwide. The company operates through four segments: U.S. Card Services, International Card Services, Global Commercial Services, and Global Network & Merchant Services.