On Friday, Shares of Heron Therapeutics Inc (NASDAQ:HRTX), lost -17.22% to $30.52.
Heron Therapeutics, declared positive, top-line results from its Phase 2 clinical study of HTX-011 in the administration of post-operative pain in patients undergoing bunionectomy. HTX-011, which utilizes Heron’s proprietary Biochronomer drug delivery technology, is a long-acting formulation of the local anesthetic bupivacaine in a fixed-dose combination with the anti-inflammatory meloxicam. The primary and all key secondary endpoints in the study were met with a high degree of statistical significance.
This randomized, placebo-controlled, double-blind, Phase 2 clinical study in 64 patients undergoing bunionectomy evaluated the efficacy and safety of HTX-011, containing 200 mg or 400 mg of bupivacaine combined with meloxicam, contrast to placebo. The primary endpoint was the difference as contrast to placebo in pain intensity as measured by the Summed Pain Intensity (SPI) score in the first 24 hours post-surgery (SPI 0-24). Key secondary endpoints comprised: the difference in SPI in the first 48 hours post-surgery (SPI 0-48); the difference in SPI in the first 72 hours post-surgery (SPI 0-72); time to the first use of opiate rescue medication; and the percent of patients who received no opiate rescue medication in the first 72 hours post-surgery. The study’s major efficacy findings for the more effective, 400 mg dose of HTX-011 as contrast to placebo comprise:
- Pain intensity in the first 24 hours post-surgery was reduced by 69% (SPI of 38.5 as compared to 124.2, p<0.0001).
- Pain intensity in the first 48 hours post-surgery was reduced by 52% (SPI of 106.9 as compared to 224.8, p<0.0001).
- Pain intensity in the first 72 hours post-surgery was reduced by 40% (SPI of 170.2 as compared to 285.9, p=0.0064).
- Time to the first use of opiate rescue medication was raised by 488% (48.2 hours as compared to 8.2 hours, p<0.0001).
- 32% of patients received no opiate rescue medication during the entire 72-hour period post-surgery, contrast to 5% for placebo (p<0.0001).
Heron Therapeutics, Inc. is a biotechnology company. The Company uses its technology to develop products to address unmet medical needs. Its Biochronomer polymer-based drug delivery platform is designed to improve the therapeutic profile of injectable pharmaceuticals. The Company’s product candidate, SUSTOL (granisetron injection, extended release), is being developed for the prevention of both acute- and delayed-onset chemotherapy-induced nausea and vomiting (CINV).
Shares of Yandex NV (NASDAQ:YNDX), declined -1.47% to $10.69, during its last trading session.
Yandex, has developed a technology for active protection of Yandex.Browser users. Called ‘Protect’, it comprises of a set of mechanisms that provide protection from the most common online dangers: phishing, malware, and interception of personal data. Yandex’s new technology prevents potential threats rather than trying to repair the damage after it has been done.
“Protect is configured so that the user is always safe,” said Roman Ivanov, the head of Yandex.Browser. “Firstly, in order for it to work, the user doesn’t have to do anything — the technology is built into the browser, the key software for using the internet. Secondly, Protect focuses on preventing harm, as opposed to dealing with the consequences. In recently’s internet, protection is necessary for practiced users and novices alike, and guaranteeing it is one of the browser’s tasks.”
Protect keeps users’ personal data safe when they use an open Wi-Fi network, for example, in a cafe or an airport. Such networks are widespread and convenient, but they can be dangerous because users’ information can be easily intercepted. Protect routes Yandex.Browser traffic through a protected server, so that intercepting the data is impossible. The technology also blocks phishing sites — resources disguised as social networks or internet banking sites with the purpose of intercepting users’ personal data. If a user enters their login and password on such a site, Protect blocks the transmission of the data and warns of the danger. Protect also makes sure users do not go to sites with malicious code and automatically checks files downloaded from the internet for any viruses. If a file turns out to be dangerous, Protect does not allow it to be opened and harm the user’s device. The technology is described in more detail on Yandex’s blog (in Russian).
Yandex N.V. operates an Internet search engine in Russia and internationally. The company offers search, location-based, personalized, and mobile services that enable users to find information, and communicate and connect over the Internet from desktops and mobile devices; and localized homepages for specific geographic markets.
At the end of Friday’s trade, Shares of Kohl’s Corporation (NYSE:KSS), lost -0.29% to $47.70.
Kohl’s, declared omnichannel and digital initiatives to support its commitment to delivering an easy shopping experience. Whether shopping in-store at Kohl’s stores nationwide, online at Kohls.com or at home or on the go on mobile devices, Kohl’s customers will discover new shopping tools counting a store mode for Kohl’s mobile app, improved mobile payment options like Apple Pay, a seamless omnichannel shopping bag across platforms and Visa Checkout on Kohls.com and on mobile. Kohl’s will also pilot same-day delivery in select markets.
“Kohl’s is committed to providing our customers with an easy, convenient shopping experience in a way that is personalized and engaging – no matter how each customer prefers to shop,” said Kevin Mansell, Kohl’s chairman, chief executive officer and president. “Our digital teams are continually testing new ideas and capabilities to create a world-class omnichannel experience that is seamless across devices. With each evolution, we aim to elevate our offerings for an easy, inspiring shopping experience.”
Kohl’s Corporation operates department stores in the United States. It offers private label, exclusive, and national brand apparel, footwear, accessories, beauty, and home products to children, men, and women customers.
Finally, Prudential Financial Inc (NYSE:PRU), ended its last trade with 1.60% gain, and closed at $77.25.
Prudential Financial Chairman and CEO John Strangfeld, Newark Mayor Ras Baraka, and many other executives and dignitaries, will celebrate the grand opening of Prudential’s new 20-story, 740,000-square-foot office tower with a ribbon cutting ceremony on September 29 at 10:30 a.m. at 655 Broad Street in downtown Newark.
The new tower is the workplace for nearly 3,000 Prudential employees.
To further support urban renewal in the neighborhood around the tower, Prudential has made more than $150 million in investments in downtown revitalization projects, such as the redevelopment of the historic Hahne & Co. Building, the restoration of Military Park and the conversion of the former National State Bank building into Hotel Indigo. These projects are assisting revive the area that once served as Newark’s town commons.
Since its founding 140 years ago, Prudential has invested $391 million throughout the city and has made noteworthygrants to enhance civic infrastructure, accelerate economic development and improve educational outcomes for Newark students.
Prudential Financial, Inc. provides insurance, investment administration, and other financial products and services to individual and institutional customers in the United States and internationally.
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