On Friday, Shares of Pfizer Inc. (NYSE:PFE), lost -1.80% to $32.66.
The Alliance Foundation Trials, LLC (AFT), the Austrian Breast & Colorectal Cancer Study Group (ABCSG) and Pfizer Inc. recently declared the launch of the Palbociclib Collaborative Adjuvant Study, or PALLAS. This global Phase 3 clinical trial for patients with early-stage breast cancer is being conducted in conjunction with Breast International Group (BIG), German Breast Group (GBG), National Surgical Adjuvant Breast and Bowel Project (NSABP) and PrECOG, LLC (PrECOG). The PALLAS trial will evaluate whether the addition of IBRANCE® (palbociclib), developed by Pfizer, to standard therapy will improve disease-free survival and prevent the disease from recurring. Patients treated in this study will have cancers that are hormone receptor-positive (HR+), meaning their growth is fueled by the hormone estrogen, but are negative for human epidermal growth factor receptor 2 (HER2-), a different tumor-associated protein. About 60 to 65 percent of breast cancers in the United States fall into this category.
A hallmark of cancer cell growth is loss of control of the cell cycle, leading to unregulated growth and spread of cancer. A promising strategy to overcome this process involves inhibition of enzymes called cyclin-dependent kinases (CDKs), which allows re-establishment of control of cell growth. Recent research has shown that two related enzymes – CDK 4 and CDK 6 – are among the primary proteins that accelerate cancer cell growth, and may be particularly important in HR+ breast tumors. iii,iv Research also indicates that combining CDK 4/6 inhibitors with endocrine therapy is beneficial in patients with advanced breast cancer. The new oral, anti-cancer drug IBRANCE blocks CDK 4/6.
Pfizer Inc., a biopharmaceutical company, discovers, develops, manufactures, and sells healthcare products worldwide. The company operates through Global Innovative Pharmaceutical (GIP); Global Vaccines, Oncology and Consumer Healthcare (VOC); and Global Established Pharmaceutical (GEP) segments.
Shares of American Airlines Group Inc. (NASDAQ:AAL), declined -1.05% to $38.62, during its last trading session.
American Airlines Group is happy to welcome fellow oneworld alliance member and Pacific Joint Business partner Japan Airlines (JAL) to Dallas/Fort Worth International Airport (DFW) with its return to service between Tokyo Narita (NRT) and DFW starting Nov. 30, 2015. American will add its code to the route.
American presently operates twice-daily service from DFW to NRT with Boeing 777-200 aircraft. JAL will offer customers service four days per week with Boeing 787-8 aircraft fitted with the airline’s latest cabin interiors and seats in a three-class configuration and is considering scheduling daily service for spring 2016.
American Airlines Group Inc., through its auxiliaries, operates in the airline industry. As of December 31, 2014, the company operated 983 mainline jets, in addition to 566 regional aircrafts through regional airline auxiliaries and third-party regional carriers. It serves 339 destinations in 54 countries.
Finally, MGM Resorts International (NYSE:MGM), ended its last trade with 1.46% gain, and closed at $20.84.
MGM Resorts International joined the American Business Act on Climate Change Pledge by pledging to reduce energy consumption 20% by 2020, during the National Clean Energy Summit held at the Mandalay Bay Resort Convention Center, sponsored by U.S. Senator Harry Reid, and with closing keynote comments by President Barack Obama.
CityCenter, an urban resort destination on the Las Vegas Strip featuring ARIA Resort & Casino, earned one of the highest LEED achievements of any hotel, retail district or residential development in the world from the U.S. Green Building Council with a Gold certification for its hotel tower, convention center and theater, Vdara Hotel & Spa, Mandarin Oriental, Las Vegas, Veer Towers and Crystals retail and entertainment district.
MGM installed the world’s largest rooftop solar array on a convention center at Mandalay Bay, stretching 20 acres and producing enough electricity to power 1,000 U.S. homes annually.
MGM Resorts International, through its auxiliaries, owns and/or operates casino resorts. It operates through two segments, Wholly Owned Domestic Resorts and MGM China. The company’s casino resorts offer gaming, hotel, convention, dining, entertainment, retail, and other resort amenities.
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