On Monday, Shares of Gilead Sciences, Inc. (NASDAQ:GILD), gained 1.00% to $99.26.
Gilead Sciences, declared that the U.S. Food and Drug Administration (FDA) has approved the use of Letairis® (ambrisentan) in combination with tadalafil for the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability. Letairis is an endothelin receptor antagonist that was first approved in 2007 in the U.S. as monotherapy for PAH to improve exercise ability and delay clinical worsening. Tadalafil is a PDE5 inhibitor that was initially approved for PAH in the U.S. in 2009 to improve exercise ability.
The new labeling is supported by data from the AMBITION study (a randomized, double-blind, multicenter study of first-line combination therapy with AMBrIsentan and Tadalafil in patients with pulmonary arterial hypertensION). In AMBITION, 605 patients with WHO Functional Class II or III PAH were randomized (2:1:1) to receive once-daily Letairis plus tadalafil (n=302) or to Letairis (n=152) or tadalafil (n=151) alone. Treatment was initiated with Letairis 5 mg and tadalafil at 20 mg. If tolerated, tadalafil was raised to 40 mg at four weeks and Letairis was raised to 10 mg at eight weeks. The primary endpoint was time to first occurrence of death, hospitalization for worsening PAH, greater than 15 percent decrease from baseline in six-minute walk distance (6MWD) combined with WHO Functional Class III or IV symptoms sustained over 14 days (short-term clinical worsening) or reduction in 6MWD sustained over 14 days combined with WHO Functional Class III or IV symptoms sustained over 6 months (inadequate long-term clinical response).
Gilead Sciences, Inc. (Gilead), is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines. The Company’s primary areas of focus include human immunodeficiency virus (HIV), liver diseases such as chronic hepatitis C virus (HCV) infection and chronic hepatitis B virus (HBV) infection, oncology and inflammation, and serious cardiovascular and respiratory conditions.
Shares of Brocade Communications Systems, Inc. (NASDAQ:BRCD), inclined 1.97% to $10.35, during its last trading session.
Brocade Communications Systems, declared that its Board of Directors has raised the authorization to repurchase its common stock under its existing stock repurchase program by $700 million, bringing the total remaining amount authorized under the program to over $1.0 billion. The timing and amounts of specific purchases will be determined by Brocade from time to time based on Brocade’s cash balances, the trading price of Brocade’s common stock, general business and market conditions, and other factors, counting alternative investment opportunities.
Since Q2 2011, Brocade has repurchased about $1.3 billion worth of its common stock, reducing Brocade’s outstanding shares by about 13 percent as of August 1, 2015.
Brocade Communications Systems, Inc. (Brocade) is a supplier of networking equipment, including end-to-end Internet Protocol-based Ethernet networking solutions and storage area networking solutions for businesses and organizations of all types and sizes, including global enterprises, and service providers, such as telecommunication firms, cable operators and mobile carriers. Brocade offers networking hardware and software products and services.
Shares of United Technologies Corporation (NYSE:UTX), inclined 2.77% to $92.26, during its last trading session.
Pratt & Whitney’s PurePower® Geared Turbofan™ (GTF) engine was cited as an Aviation Climate Solution by the Air Transport Action Group (ATAG) at the Global Sustainable Aviation Summit in Geneva, Switzerland. Pratt & Whitney is a United Technologies Corp. (UTX) company.
The GTF’s engine technology reduces commercial aircraft fuel burn and carbon dioxide emissions by more than 16 percent, reduces regulated emissions by more than 50 percent and will reduce CO2 emissions at a level equivalent to planting nearly 1 million trees or removing 3 million cars off the road – every year. The engine reduces the aircraft noise footprint by more than 75 percent. Five airframers have chosen the GTF engine to power their new aircraft or re-engine existing models.
Pratt & Whitney’s GTF is comprised as part of the Aviation Climate Solutions, a collection of 100 examples of partnership within the aviation industry to cut carbon dioxide emissions and assist reduce its impact on climate change.
United Technologies Corporation (UTC) provides high technology products and services to the building systems and aerospace industries across the world. The Company operates through five segments: Otis; UTC Climate, Controls & Security; Pratt & Whitney; UTC Aerospace Systems and Sikorsky.
Finally, Spectrum Brands Holdings, Inc. (NYSE:SPB), ended its last trade with 1.08% gain, and closed at $96.38.
Spectrum Brands Holdings, declared that Chief Executive Officer and President Andreas Rouvé has been elected to the Company’s Board of Directors, effective October 1. Mr. Rouvé, 53, became CEO and President on April 1, 2015.
The Company also declared that David R. Lumley, stepped down Chief Executive Officer and President, has elected to resign from the Board of Directors, effective September 30 and consistent with his overall plans to ensure a smooth and orderly transition to his successor and with the end of his transition services employment agreement on September 30, 2015. Mr. Lumley, 61, served as a Director since April 2010.
Spectrum Brands Holdings, Inc. (SB Holdings) is a consumer products company. The Company supplies consumer batteries, residential locksets, residential builder’s hardware, plumbing and accessories, shaving and grooming products, personal care products, small household appliances, specialty pet supplies, lawn and garden and home pest control products, personal insect repellents and auto care products.
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